Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine Carnitine Shuttle Purpose and Mechanism Role of carnitine in disease Nutrition & Metabolism Springer Nature Link Role of L carnitine in the transportation of long chain fatty acid across the mitochondria membrane. Carnitine metabolism in hypertensive heart failure Hypertension Research