G6PDH from baker s yeast (S. cerevisiae), lyophilized powder File:Glutathion metabolism DE state in G6PD deficiency.png Wikimedia Commons Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis. Pediatrics #12 MEHLMANMEDICAL